A series of new imidazolo quinoline analogs AZ-1, AZ-2, AZ-3 and AZ-4 {1-(2-((18Z)-4-substituted benzylidene-4, 5- dihydro-5-oxo-2-phenylimidazol-1-yl) ethyl)-1, 2-dihydro-4-methyl-2-oxoquinolin-7-yl substitutes} were screened for some CNS activities. The observations on general behavioral profile, exploratory behavior {Elevated plus maze (EPM), Light dark apparatus (LDA), Hole board apparatus (HBA), Open field apparatus (OFA) and Marble burrying test (MBT)}, pentylenetetrazole (PTZ) induced convulsions, tail suspension test (TST), forced swim test (FST), haloperidol induced catatonia, hot plate test (HPT), tail immersion test (TIT), pentobarbital induced sleep time and sodium nitrite induced hypoxia were carried out. The mice were administered per orally with test compounds (10, 30 mg/kg) and were compared with the control group. The results indicated that AZ-2 (30 mg/kg) showed anti anxiety effects and potentiated pentobarbital (PB) induced sleep time. The compound may have GABA potentiating effect.
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